Category:
Vascular Health / Performance / Sexual Health
Ipamorelin (10mg)
Benefits & Mechanism:
Like GHRP-2, Ipamorelin enhances GH secretion but with fewer side effects and a cleaner receptor profile. Increased GH/IGF-1 promotes NO-mediated vasodilation, helping with circulation, recovery, and muscle perfusion during training.
Dosing & Protocol:
Reconstitution:
10 mg vial → 1ml or 5ml bacteriostatic water depending on the desired concentration and ease of dosing.
1mL of bacteriostatic water results in a higher concentration (10mg/mL or 10,000 mcg/mL), which means you will draw a very small volume for your dose.
5mL provides a lower concentration (2mg/mL or 2,000 mcg/mL), making it easier to measure precise microgram (mcg) doses with a standard insulin syringe.
Daily Dose:
2 mg → 100–200 mcg (10–20 units)
5 mg → 200 mcg (10 units)
Cycle: 5 days on / 2 days off, 4–5 weeks
Timing: Before bedtime on an empty stomach
Route: Subcutaneous (SQ) injection
MT-2 (Melanotan II) – 10mg
Benefits & Mechanism:
MT-2 activates melanocortin receptors, which stimulate NO release in penile and vaginal tissues, explaining its role in arousal and sexual function. It also improves skin resilience, indirectly protecting NO by reducing oxidative stress.
Dosing & Protocol:
Reconstitution: 3 ml bacteriostatic water
Daily Dose: 166 mcg (5 units)
Cycle: 1–3 times per week for up to 2 weeks, then reduce to once weekly
Timing: On an empty stomach or with a light meal
Route: Subcutaneous (SQ) injection
PT-141 – 10mg
Benefits & Mechanism:
PT-141 works through the central melanocortin system to trigger arousal but relies on NO-mediated vasodilation for erection and genital response. Unlike PDE-5 inhibitors, it does not act directly on blood vessels, but enhances NO release through neural signaling.
Dosing & Protocol:
Reconstitution: 2 ml bacteriostatic water
Daily Dose: 500 mcg (10 units) → up to 2 mg (40 units)
Cycle: 3x per week (Mon/Wed/Fri); start at 500 mcg and titrate upward
Timing: Based on personal preference
Route: Subcutaneous (SQ) injection
TB-500 – 5mg
Benefits & Mechanism:
TB-500 enhances angiogenesis and endothelial repair via upregulation of VEGF and eNOS pathways. This improves microcirculation, tissue oxygenation, and overall NO bioavailability — critical for healing, vascular resilience, and performance.
Dosing & Protocol:
Reconstitution:
5 mg vial → 2.5 ml
Daily Dose:
5 mg → 200–400 mcg (10–20 units)
Cycle: 5 days on / 2 days off, 4–5 weeks
Timing: Morning, on an empty stomach, at least 30 minutes before eating
Route: Subcutaneous (SQ) injection
Potential Side Effects (from dosing guide)
Ipamorelin: Water retention, appetite changes, flushing, tingling
MT-2: Nausea, flushing, pigmentation changes (freckles/moles may darken), increased libido
PT-141: Nausea, headache, flushing, transient blood pressure changes
TB-500: Mild fatigue, injection-site redness, headache
Suggested Nitric Oxide (NO) Supporting Stacks
Cardiovascular
health & circulation: TB-500, IpamorelinExercise performance & recovery: Ipamorelin, TB-500
Sexual function & arousal: PT-141, MT-2
Disclaimer:
This article is for educational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before beginning any peptide or supplement regimen.